In the sixteenth century, Paracelsus observed that every substance is poisonous. Toxicologists strive to determine the toxicity of substances using methodologies such as computer modeling, cellular and genetic toxicology, and animal studies. Toxicity evaluations, toxicity clearances, wildlife toxicity assessments, and environmental health assessments are some of the products used to evaluate risks to Soldiers, civilians and the environment posed by military-unique and military-relevant substances.


Animal Models

This page discusses using animal models for toxicology experiments.

Genetic and Cellular Toxicology

This page discusses assays used by the APHC for genetic and cellular toxicology.


A brief discussion on the use of genomics by the Toxicology Portfolio.

Toxicological Computer Modeling

The computer modeling page describes the benefits of "in silico" experiments and the types of modeling used by the APHC.

Toxicology Partner Organizations

The collaboration page lists some of the entities with which the APHC joins forces.


Fish and Wildlife Exposure Modeling

Exposure modeling software including FishRand-Migration (FR-M) and the Spatially-Explicit Exposure Model (SEEM) are available by contacting the Toxicology Portfolio. A life history and bioaccumulation document is also available.

Toxicity Clearances

A toxicity clearance is a toxicological evaluation of materials prior to their introduction into the Army supply system.

Wildlife Toxicity Assessments

A Wildlife Toxicity Assessment is a standard method for developing toxicological profiles and toxicity reference values for military-related substances that may pose risks to wildlife.